Invention Description Conventional fiber optic surface modifications rely on porous silica substrates, which are brittle and optically limited. While polymers such as PMMA and polyvinylidene fluoride (PVDF) offer superior mechanical flexibility and optical clarity, their relatively inert surfaces resist functionalization via traditional methods. ...

Invention Description In the rapidly evolving field of live-cell analysis, recent innovations have enabled the sensing and quantification of specific intracellular nucleic acid targets, such as messenger RNA (mRNA) and other RNA species, in viable cells without requiring cell lysis or destruction of the sample. This capability is critical for drug...

Invention Description Accurately identifying and sequencing rare genotypes within complex cell populations remains a major challenge across biological research. Conventional sequencing approaches often require large amounts of high-quality DNA, struggle with heterogeneous or degraded samples, and fail to retain the spatial or cellular context necessary...

Invention Description In modern airtight vehicles, the concentration of air pollutants, including CO2, can build up quickly, with some studies showing a rise above 2500 ppmv of CO2 in mere minutes in occupied vehicles. This is particularly noticeable during recirculated air operation and in urban or hot climates where cabin air is recirculated to enhance...

Invention Description Polyaniline (PANI) is a conductive polymer with excellent electrical conductivity lending it great utility in numerous electronics applications including electronic devices, sensors, batteries and more. While PANI can be easily deposited on many surfaces, it has difficulty with producing a dense coating on insulating substrates,...

Point-of-care (POC) testing techniques are essential in molecular diagnostics, particularly in resource-limited settings. The first step in molecular diagnostics is sample preparation which may include extraction of nucleic acids (NAs). Simple and efficient NA extraction is crucial for downstream applications such as pathogen detection, genetic analysis,...

Fluorescence based point-of-care molecular diagnostic systems are ubiquitous in healthcare. However, many tests require that the sample be sent to a reference laboratory and read by trained medical staff which can be expensive and result in delayed analysis. Portable systems have been developed, however, detecting multiple biomarkers requires a different...

Nitric species such as nitric oxides are important environmental pollutants as well as key breath biomarkers of respiratory diseases. A chemical sensor that can quickly, selectively and sensitively detect these analytes will find applications not only in environmental monitoring, but also as a non-invasive medical diagnosis and management device. Current...

Studying single cells is difficult due to the laborious and costly cell isolation procedures which restrict throughput and impede the analysis of large numbers of cells or multiple samples in a single experiment. ASU researchers previously developed a method which used the cell’s membrane as a container for different reactions. One such reaction...

Molecular interactions are integral to virtually all biological processes including cell signaling, enzyme activity, protein functionality, and disease development. Understanding the kinetics of these interactions is crucial for providing detailed quantitative and mechanistic insights, at the molecular level, which are essential for advancements in...