Invention Description Irritable bowel syndrome (IBS) is a prevalent and multifactorial gastrointestinal disorder that affects 10-15% of the US population. Because the pathophysiology of IBS remains poorly understood, current diagnostic tools and treatments are limited, with diagnosis often relying on symptom-based assessments and exclusion of other...

Invention Description Orthopox monkeypox (MPXV) has recently emerged as a global viral threat with two distinct clades identified as endemic pathogens. It is estimated that 70% of the world’s population is vulnerable to infection by members of orthopoxviridae. Rapid identification of MPXV clades is critical, as Clade I infections are more clinically...

Invention Description Multimodal large language models (MLLMs) have shown strong potential in analyzing complex data types such as images, video, and audio, prompting growing interest in their use for medical applications. While several general-domain MLLMs have been adapted for healthcare tasks, including retinal imaging, their performance remains...

Invention Description Lyophilization is a critical process for stabilizing reagents in point-of-care (POC) diagnostics, effectively eliminating the need for cold chain storage and preventing liquid evaporation. While this technology is essential for developing robust field-deployable devices, current industry standards are limited to producing reagents...

Invention Description Lab-on-a-chip technology and microfluidic diagnostic devices often rely on complex mechanical or electrical systems to manipulate fluid, making them costly and bulky. These components may limit portability, decrease operational lifetime, and prevent widespread use by untrained personnel or patients at the point of care or at home....

Invention Description Rapid and reliable nucleic acid assays are critical for diagnosing infectious diseases at the point of need, yet most systems rely on complex, expensive instrumentation and trained personnel. These requirements limit access to timely diagnostics in low-resource, remote, or decentralized settings. Many platforms typically require...

Invention Description Accurately identifying and sequencing rare genotypes within complex cell populations remains a major challenge across biological research. Conventional sequencing approaches often require large amounts of high-quality DNA, struggle with heterogeneous or degraded samples, and fail to retain the spatial or cellular context necessary...

Invention Description Pediatric Inflammatory Bowel Disease (IBD), encompassing Crohn’s Disease and Ulcerative Colitis, presents significant clinical challenges due to its complex and heterogeneous nature, often leading to lifelong health complications. Current diagnostic and therapeutic strategies are limited by an incomplete understanding of...

Invention Description Understanding of the pathobiology of Alzheimer’s disease (AD) has long been fragmented, with much research centered around biological mechanisms including amyloid β or tau proteins, inflammation, cell death pathways, glia, mitochondria and more. While these all deal with real facets in the biology of AD, they are limited...

Implementing liquid-based assays, such as PCR and LAMP, is difficult in POC microfluidic devices, due to bubble formation. To mitigate this, auxiliary metering systems or actuators are required to regulate consistent flow rates. This can make the microfluidic device more complicated to operate, increases cost, and limits rapid prototyping, ultimately...