Natural compounds are a productive and promising source of novel anticancer and antiproliferative drugs. Dr. Pettit and his team have been at the forefront of discovering, isolating and synthesizing such compounds having anticancer and antimicrobial activities for many years. Current developments in the antibody-drug conjugate (ADC) space have sparked...

The early promise of pancratistatin as a new type of anticancer and antiviral drug led to various preclinical developments. While there have been improvements to the availability of pancratistatin by the development of new horticultural and synthetic approaches, still there is a need for more efficient techniques for the conversion of pancratistatin...

The actinomycete genus Kitasatospora has a prominent history of producing bioactive compounds, including bafilomycin B1 and bafilomycin A1. One particular compound isolated from Kitasatospora, respirantin, is a cyclodepsipeptide with potential cancer cell growth inhibitory and antifungal/antimicrobial properties. A need exists to isolate and modify...

The remarkable anticancer properties of dolastatin 10, isolated from the sea hare (sea slug) Dolabella auricularia, have led to interest in closely related derivatives (auristatins) suitable for clinical trials. Most recently, such auristatins have been linked to antibodies for delivery. In many indications, however, it would be desirable to deliver...

The promise of marine derived microorganisms as productive sources of new anticancer and antiproliferative drugs continues to expand. Previously, Dr. Pettit and his team isolated and determined the structures of two very potent cancer cell growth inhibitors, cyclodepsipeptides from Bacillus silvestris, carried by a South Pacific crab. Subsequently,...

The promise of natural compounds as productive sources of new anticancer and antiproliferative drugs continues to expand. Dr. Pettit and his team have been at the forefront of discovering, isolating and synthesizing natural compounds for anticancer and antimicrobial activities as well as other indications for a long time. With the recent developments...

Natural compounds are a productive and promising source of new anticancer and antiproliferative drugs. Dr. Pettit and his team have been at the forefront of discovering, isolating and synthesizing such compounds with anticancer and antimicrobial activities for a long time. Current developments in the antibody-drug conjugate (ADC) space have sparked...

Contact Jack Geltosky, PhD Senior Vice President of Business Development, Life Sciences Arizona Technology Enterprises, LLC (AzTE) P: 480.884.1989 F: 480.884.1984 JGELTOSKY@AZTE.COM Inventors George Pettit, PhD Regents Professor Department of Chemistry and Biochemistry Arizona State University Rui Tan Feng Gao Yoshitatsu...