Mitochondrial diseases are a group of disorders associated with dysfunctional mitochondria, often caused by genetic mutations to mitochondrial DNA. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Energetic defects have been implicated in forms of movement disorders, cardiomyopathy,...

Mitochondrial diseases are a group of disorders associated with dysfunctional mitochondria, often caused by genetic mutations to mitochondrial DNA. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Energetic defects have been implicated in forms of movement disorders, cardiomyopathy,...

Mitochondrial diseases are a group of disorders associated with dysfunctional mitochondria, often caused by genetic mutations to mitochondrial DNA. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Energetic defects have been implicated in forms of movement disorders, cardiomyopathy,...

Mitochondria are intracellular organelles responsible for a number of metabolic transformations and regulatory functions. They produce much of the ATP employed by eukaryotic cells. They are also the major source of free radicals and reactive oxygen species that cause oxidative stress. Mitochondrial defects are damaging, particularly to neural and...

Diagnosing and monitoring diseases and health often requires detecting and measuring concentrations of one or more analytes in a patient. Frequent trips to a healthcare facility are onerous and expensive and at home testing is painful, sometimes laborious and time consuming. All of this may lead to a lack of regular testing, and could mean missed diagnoses...

Alzheimer's disease (AD) is one of the most prevalent and feared neurodegenerative diseases associated with aging, characterized by progressive neuronal loss and cognitive dysfunction. AD affects nearly 5 million Americans, and unfortunately, there is no cure as of yet. Numerous studies have implicated oligomeric amyloid beta (Aß) aggregates as...

Alzheimer’s disease (AD) is one of the most prominent and feared neurodegenerative diseases associated with aging. A hallmark of this disease is the formation of extra-cellular amyloid plaques in the brain. The principle component of these extracellular plaques is amyloid-ß protein (Aß). Though the mechanisms underlying Alzheimer’s...

Despite decades of research, cancer remains one of today’s most pressing health concerns. Traditional treatment approaches such as radiation therapy and chemotherapy can cause systemic toxicity and become ineffective when resistant tumors emerge. Recently, anticancer strategies have focused on drugs which specifically target tumor-related biological...

Background Real-time immediate feedback is known to enhance learning by providing better engagement with learners, as seen in a classroom environment with teachers. Applications with automated feedback are designed to mimic the prompt feedback provided by teachers in a classroom. Advances in artificial intelligence (AI) technology have enabled this...

­Background Current glucose monitoring solutions include minimally invasive continuous blood glucose monitoring using implantable enzymatic sensors. However, biomacromolecule binding can cause foreign body reactions, and long-term implanted sensors can give rise to biocompatibility issues. These drawbacks make difficult the clinical promotion of...