Invention Description While recent advances have made RNA therapeutics and vaccines more mainstream, they still suffer from drawbacks including high-dosing requirements and the inability for conditional and targeted expression. Further, they can experience off-target gene expression and related side effects as well as challenges in tissue- or cell-specific...

Human Leukocyte Antigens (HLA) are protein complexes residing on cell surfaces responsible for regulating immune responses. HLA haplotype sequencing is integral to the development of personalized therapies and diagnostics. It is also paramount to the understanding of T cell mediated immunity. There are over six classical major HLA loci with over 32,000...