Human blood plasma and serum (P/S) samples from clinical studies are often archived by biobanks for future research. Biospecimen integrity is crucial for ensuring the validity of clinically oriented research. P/S samples are not intrinsically stable. Inappropriate handling and storage conditions can result in protein oxidation, which can dramatically...

Mass spectrometry (MS) analysis is a ubiquitous and important analytical technique in protein research and analysis. Some of the most common technical issues involve low-concentration solutions (sub-µM) with their attendant adsorptive loss and oxidation of proteins to be analyzed. Carrier proteins are sometimes used to prevent adsorptive protein...