Cancer biologists have known for decades that tumor cells display aberrant sugar polymer (glycan) structures. This means that if glycans can be analyzed in the right way(s), they should serve as excellent markers for the presence and progression of cancer. Altered activity of the enzymes that build glycans (glycotransferases, GTs) is the immediate upstream...

Human blood plasma and serum (P/S) samples from clinical studies are often archived by biobanks for future research. Biospecimen integrity is crucial for ensuring the validity of clinically oriented research. P/S samples are not intrinsically stable. Inappropriate handling and storage conditions can result in protein oxidation, which can dramatically...

Mass spectrometry (MS) analysis is a ubiquitous and important analytical technique in protein research and analysis. Some of the most common technical issues involve low-concentration solutions (sub-µM) with their attendant adsorptive loss and oxidation of proteins to be analyzed. Carrier proteins are sometimes used to prevent adsorptive protein...