In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...

Nanotechnology has grown by leaps and bounds in the past few decades. One of the main goals of nanotechnology is to build machines, switches or devices at the subatomic level that operate in a stimulus-responsive manner. Because DNA, via Watson-Crick pairing, is so precisely programmable, it is an ideal building block for creating such systems. In fact,...