Invention Description Personalized human-sensing systems, especially in clinical and health applications, often struggle with limited user-specific data and significant variability between individuals. Differences in physiology, behavior, and environmental conditions can cause performance drops when models trained on general datasets are applied to...

Invention Description In the event of a terrorist attack or nuclear accident where large populations of individuals are exposed to radiation, it is critical for authorities to have the ability to quantify and confirm the levels of absorbed radiation. It is also essential for authorities to identify if an individual is exposed to greater than 2Gy where...

Invention Description In the rapidly evolving field of live-cell analysis, recent innovations have enabled the sensing and quantification of specific intracellular nucleic acid targets, such as messenger RNA (mRNA) and other RNA species, in viable cells without requiring cell lysis or destruction of the sample. This capability is critical for drug...

Invention Description Lyophilization is a critical process for stabilizing reagents in point-of-care (POC) diagnostics, effectively eliminating the need for cold chain storage and preventing liquid evaporation. While this technology is essential for developing robust field-deployable devices, current industry standards are limited to producing reagents...

Invention Description Rapid and reliable nucleic acid assays are critical for diagnosing infectious diseases at the point of need, yet most systems rely on complex, expensive instrumentation and trained personnel. These requirements limit access to timely diagnostics in low-resource, remote, or decentralized settings. Many platforms typically require...

Invention Description Wireless capacitive pressure sensors have been widely studied for health monitoring applications including continues monitoring of blood flow in patients suffering from high blood pressure, tracking of bladder pressure in patients with urine incontinence, and monitoring intracranial pressure in patients experiencing traumatic...

Invention Description Understanding of the pathobiology of Alzheimer’s disease (AD) has long been fragmented, with much research centered around biological mechanisms including amyloid β or tau proteins, inflammation, cell death pathways, glia, mitochondria and more. While these all deal with real facets in the biology of AD, they are limited...

Implementing liquid-based assays, such as PCR and LAMP, is difficult in POC microfluidic devices, due to bubble formation. To mitigate this, auxiliary metering systems or actuators are required to regulate consistent flow rates. This can make the microfluidic device more complicated to operate, increases cost, and limits rapid prototyping, ultimately...

Point-of-care (POC) testing techniques are essential in molecular diagnostics, particularly in resource-limited settings. The first step in molecular diagnostics is sample preparation which may include extraction of nucleic acids (NAs). Simple and efficient NA extraction is crucial for downstream applications such as pathogen detection, genetic analysis,...

Neurodegenerative diseases such as Alzheimer’s are affecting an increasing number, with annual new diagnoses approaching one-half million; and total cost, $150 billion. Early diagnosis and treatment are important for optimal outcomes, yet there is currently no test to detect such diseases in their early, asymptomatic stages. Active immuniza-tion...