Invention Description In the event of a terrorist attack or nuclear accident where large populations of individuals are exposed to radiation, it is critical for authorities to have the ability to quantify and confirm the levels of absorbed radiation. It is also essential for authorities to identify if an individual is exposed to greater than 2Gy where...

The incidence of inflammatory bowel disease (IBD), which includes Chron’s disease (CD) and ulcerative colitis (UC), is increasing globally, as is the healthcare burden, with studies showing it as one of the top 5 most expensive GI conditions. Early and accurate diagnosis is strongly associated with better patient outcomes. However, the common...

Understanding the relationship between protein sequence-structure and binding dynamics is not well understood. Of particular interest is the ability to relate foldability and function of a protein and the ability to characterize how foldability and binding change based on mutations in the protein sequence. WW domains are one of the most abundant independently...

To reduce costs and increase the availability of personalized genomics new approaches to DNA sequencing are required. Nanopore sequencing is one proposed technique. In nanopore sequencing, DNA molecules are forced through a tiny aperture by electrophoresis. As the individual bases transit the nanopore, their identity can be determined, in theory, by...

The US Government’s pursuit of the “Thousand Dollar Genome” and the “X Prize” goal of even lower cost DNA sequencing are striking examples of the importance being assigned to advances in methods for the DNA sequencing of the human genome. The first technology that finally allows for truly routine genome sequencing will...

The US Government's pursuit of the "Thousand Dollar Genome" and the "X Prize" goal of even lower cost DNA sequencing are striking examples of the importance being assigned to advances in methods for the DNA sequencing of the human genome. The first technology that finally allows for truly routine genome sequencing will open a new...

the second most common cancer in both men and women and the leading cause of cancer death in the US. Although there are risk factors for lung cancer, such as smoking, there are many cases where the patient never smoked. Because of this, there is growing interest in investigating the lung microbiota and how that may promote or prevent disease. Yearly...

Autoantibodies are an excellent biomarker for both autoimmune disease and cancer, however, some autoantibodies, called common autoantibodies, have been found to occur frequently in healthy individuals. The presence of these common autoantibodies can impede the search for disease-linked autoantibodies or lead to false positives. The identification of...

Autoantibodies are an excellent biomarker for both autoimmune disease and cancer, however, some autoantibodies, called common autoantibodies, have been found to occur frequently in healthy individuals. The presence of these common autoantibodies can impede the search for disease-linked autoantibodies or lead to false positives. The identification of...

Gastric cancer (GC) is a major public health problem in many countries, with more than 1 million new cases, worldwide, in 2020, contributing to almost 800,000 deaths. And new research suggests that GC may be on the rise in the US, particularly among younger adults. Early detection of GC often allows for greater therapeutic options, however, because...