Mitochondrial diseases are a group of disorders associated with dysfunctional mitochondria, often caused by genetic mutations to mitochondrial DNA. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Energy effecting defects have been implicated in forms of movement disorders, cardiomyopathy,...

It is becoming increasingly apparent that mitochondrial dysfunction plays a critical role in numerous human diseases. Yet, there are no approved drugs designed to directly target mitochondria. To develop new therapeutics that target mitochondria, ideally, a mitochondrial targeting moiety would be utilized. Although several functionalities have been...

Mitochondrial diseases are a group of disorders associated with dysfunctional mitochondria, often caused by genetic mutations to mitochondrial DNA. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Energy effecting defects have been implicated in forms of movement disorders, cardiomyopathy,...