The amount of time and money that goes into getting a drug from initial discovery to FDA approval is substantial, typically involving at least 10 years and hundreds of millions of dollars. Because of this, there has been a growing interest in repurposing drugs which have previously been approved for human use, particularly since their MOA as well as...

Mitochondrial diseases are a group of disorders associated with dysfunctional mitochondria, often caused by genetic mutations to mitochondrial DNA. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Energy effecting defects have been implicated in forms of movement disorders, cardiomyopathy,...

Diagnosing and monitoring diseases and health often requires detecting and measuring concentrations of one or more analytes in a patient. Frequent trips to a healthcare facility are onerous and expensive and at home testing is painful, sometimes laborious and time consuming. All of this may lead to a lack of regular testing, and could mean missed diagnoses...

High throughput parallel assays are needed to effectively identify and study biomolecules and their activity. Typically it takes a large number of repeated assays to get statistically significant data for studying biomolecules. However, fewer assays would be needed to get statistically meaningful results if the data were of higher quality. Because of...

Antibiotic resistance is a worldwide clinical and public health problem, primarily stemming from the overuse of antibiotics. One of the most critical resistant pathogens is Methicillin-resistant Staphylococcus aureus (MRSA), which accounts for over 2,000,000 illnesses and 11,000 deaths each year. MRSA has developed resistance to all beta-lactam antibiotics....

The ability to measure molecular binding and interactions is important for understanding many biological processes. Particularly important is detecting the binding of small molecule drugs with their corresponding membrane protein receptors, which currently account for more than half of all drug targets. For effective measurements, purified membrane...