It is becoming increasingly apparent that mitochondrial dysfunction plays a critical role in numerous human diseases. Yet, there are no approved drugs designed to directly target mitochondria. To develop new therapeutics that target mitochondria, ideally, a mitochondrial targeting moiety would be utilized. Although several functionalities have been...

Many early stage cancers have a high rate of survival if promptly diagnosed and treated. Survival rates for stage 1-3 breast cancer can be as high as 95% at the 5 year mark. Unfortunately, late stage cancers have a much lower survival rate; stage 4 breast cancer only has about a 20% survival rate at the 5 year mark. Metastatic cancers pose a particularly...

Recent studies conclude that a strong correlation exists between the numbers of glomerular in the kidney and renal diseases. These findings generate great interest in accurately counting glomeruli. Traditionally, the glomerulus is counted using histological sections, which have several limitations. First, histology based counting relies on techniques...