In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...

The ability to create nano- and meso-scopic structures with precise geometry is of immense interest and value in nanotechnology. Self-assembly with building blocks that encode the details of the structure is highly promising, but difficult to realize because of kinetic traps and unwanted byproducts. Although possible, it often requires painstaking trial-and-error...