In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...

Background Recent advances in catalysis by single-atom catalysts (SACs) and cluster catalysts have highlighted the unique catalytic properties of highly dispersed metal species. The use of single metal atoms or small clusters for catalysis is not only cost-effective but also significantly enhances the selectivity of a targeted reaction, resulting in...

Background Noble metal-based catalysts have been widely utilized as emission control catalysts. However, most of the noble metal-based catalysts used in heterogeneous catalysis have a low atom efficiency since their dispersion is much less than 100%, especially for larger nanoparticles. This significantly increases the usage of noble metal in order...