Live recombinant attenuated Salmonella-vectored vaccines hold great promise as a means to improve human health by generating long-lasting mucosal, humoral and cellular immunity against Salmonella and a variety of non-Salmonella pathogens at a low cost. Salmonella Typhimurium elicits a robust host immune response by targeting M cells present on the luminal...

Necrotic enteritis (NE), caused by type A strains of the bacterium Clostridium perfringens, results in a global economic loss of over 2 billion dollars, annually, to the poultry industry. C. perfringens causes chronic sub-clinical intestinal mucosal damage, leading to a reduction in the ability of birds to benefit from nutrients in food and reduced...