Studying single cells is difficult due to the laborious and costly cell isolation procedures which restrict throughput and impede the analysis of large numbers of cells or multiple samples in a single experiment. ASU researchers previously developed a method which used the cell’s membrane as a container for different reactions. One such reaction...

Protein misfolding plays a role in degenerative diseases, cancer evolution, synthetic biology, bioproducts, and more. Despite its importance in all of these fields, researchers often struggle to understand even the basic mechanisms of protein misfolding. For example, there is no tool to determine how much misfolding is happening inside of any given...

­Sequencing platforms have come a long way and are now capable of delivering enormous amounts of high-quality data, allowing for the possibility of sequencing the genomes of thousands of individual cells. Single-cell sequencing enables the examination of heterogeneity within populations and identifying rare or low frequency mutations that contribute...