Invention Description Accurately identifying and sequencing rare genotypes within complex cell populations remains a major challenge across biological research. Conventional sequencing approaches often require large amounts of high-quality DNA, struggle with heterogeneous or degraded samples, and fail to retain the spatial or cellular context necessary...

Studying single cells is difficult due to the laborious and costly cell isolation procedures which restrict throughput and impede the analysis of large numbers of cells or multiple samples in a single experiment. ASU researchers previously developed a method which used the cell’s membrane as a container for different reactions. One such reaction...

­Sequencing platforms have come a long way and are now capable of delivering enormous amounts of high-quality data, allowing for the possibility of sequencing the genomes of thousands of individual cells. Single-cell sequencing enables the examination of heterogeneity within populations and identifying rare or low frequency mutations that contribute...