Search Results - molecular+diagnostics

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  1. Single Cell In-Situ Extraction with Intact 3D Morphology from Formalin Fixed Paraffin Embedded (FFPE) Tissues
    FFPE is a well-established and widely used method for preservation and histological analysis of tissue samples. DNA/RNA/and Proteins can be extracted from FFPE samples, but generally lack single cell resolution and completely lack 3D spatial resolution. Enabling 3D resolution allows the correlation of morphology to information like gene expression,...
    Published: 2/13/2025
    Inventor(s): David Richardson, Thai Tran, Dmitry Derkach, Colleen Ziegler
    Keywords(s): Bioanalysis, Biological Cell Manipulation, Bio-Technology, Cancer, Device, Diagnostics, Gene Expression, Genomics, Proteomics, In situ, Molecular Diagnostics, Single-cell analysis
    Category(s): Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools
  2. Optimized Carbohydrates for Tumor Targeting
    The bleomycins (BLMs) are well-known antineoplastic agents, clinically useful in the treatment of squamous cell carcinomas and malignant lymphomas. The carbohydrate moiety, particularly the disaccharide moiety, of BLM is also known to be highly tumor targeting. Researchers at the Biodesign Institute of Arizona State University have discovered disaccharides...
    Published: 2/13/2025
    Inventor(s): Sidney Hecht, Manikandadas Mathilakathu Madathil, Chandrabali Bhattacharya, Trevor Bozeman, Rakesh Paul, Zhiqiang Yu, Michael Rishel
    Keywords(s): Diagnostics, Drug Target Identification, Imaging, Medical Devices and Imaging, Molecular Diagnostics
    Category(s): Life Science (All LS Techs), Imaging, Medical Imaging, Pharmaceuticals
  3. Microreactor Array Instrument/Platform
    High throughput parallel assays are needed to effectively identify and study biomolecules and their activity. Typically it takes a large number of repeated assays to get statistically significant data for studying biomolecules. However, fewer assays would be needed to get statistically meaningful results if the data were of higher quality. Because of...
    Published: 2/13/2025
    Inventor(s): Peter Wiktor
    Keywords(s): Array Techs - Micro, Nano, Gen,Proteomic, Bioassay, Bio-Technology, Detection, Diagnostics, Diffusion, DNA nanotechnology, Drug Discovery, Drug Screening, Drug Target Identification, ELISA, Genomics, Proteomics, Health Monitoring, High Throughput Sensors, Immunology, In situ, In Vitro, Instrumentation, Liquid Handling and Dispensing, MicroArray, Microbiology, Micro-Fluidics, Microreactor, Molecular Diagnostics, Nucleic Acid, Personalized medicine, Pharmaceutical, Polymerase Chain Reaction (PCR), Protein, Protein Assays
    Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Genomic Assays/Reagents/Tools, Proteomic Assays/Reagents/Tools
  4. Probes and Methods for Measuring Tandem Repeats
    Telomeres, tandem repeats at the ends of chromatids, are a particular point of interest in the science of aging and cancer. Telomeric DNA is lost during cellular replication, resulting in shortened chromatid length and cessation of cell division. Many age-related diseases are linked to shortened telomeres. Conversely, many cancer cells demonstrate elongated...
    Published: 2/13/2025
    Inventor(s): Fusheng Xiong, Wayne Frasch
    Keywords(s): Bioassay, biomarker, Cancer, Diagnostics, DNA nanotechnology, Early Detection, Molecular Diagnostics, Personalized medicine, PS-Bioengineering, Medical, Sensors, Singe molecule analysis, Telomerase
    Category(s): Life Science (All LS Techs), Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Genomic Assays/Reagents/Tools
  5. Glycan Nodes: Multiplexed Glycotransferase Surrogate Analysis for Detecting and Monitoring Cancer
    Cancer biologists have known for decades that tumor cells display aberrant sugar polymer (glycan) structures. This means that if glycans can be analyzed in the right way(s), they should serve as excellent markers for the presence and progression of cancer. Altered activity of the enzymes that build glycans (glycotransferases, GTs) is the immediate upstream...
    Published: 2/13/2025
    Inventor(s): Chad Borges, Douglas Rehder
    Keywords(s): Biosignature, Cancer, Detection, Glycans, Health Monitoring, Molecular Diagnostics, Personalized medicine
    Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs)
  6. Biomarkers for Irritable Bowel Syndrome (IBS)
    Approximately 9% of the general population will report the onset of Irritable Bowel Syndrome (IBS) over a one year period. Unfortunately, at present, there is no standard and reliable diagnostic test for IBS. IBS is currently diagnosed using symptomatic criteria, but because symptoms of IBS can overlap with other GI diseases, there is considerable uncertainty...
    Published: 2/13/2025
    Inventor(s): Todd Sandrin, Peter Jurutka
    Keywords(s): Biosignature, Bio-Technology, Gene Expression, Genomics, Proteomics, MicroArray, Molecular Diagnostics
    Category(s): Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Medical Diagnostics/Sensors

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