To reduce costs and increase the availability of personalized genomics new approaches to DNA sequencing are required. Nanopore sequencing is one proposed technique. In nanopore sequencing, DNA molecules are forced through a tiny aperture by electrophoresis. As the individual bases transit the nanopore, their identity can be determined, in theory, by...

The US Government’s pursuit of the “Thousand Dollar Genome” and the “X Prize” goal of even lower cost DNA sequencing are striking examples of the importance being assigned to advances in methods for the DNA sequencing of the human genome. The first technology that finally allows for truly routine genome sequencing will...

The US Government's pursuit of the "Thousand Dollar Genome" and the "X Prize" goal of even lower cost DNA sequencing are striking examples of the importance being assigned to advances in methods for the DNA sequencing of the human genome. The first technology that finally allows for truly routine genome sequencing will open a new...

the second most common cancer in both men and women and the leading cause of cancer death in the US. Although there are risk factors for lung cancer, such as smoking, there are many cases where the patient never smoked. Because of this, there is growing interest in investigating the lung microbiota and how that may promote or prevent disease. Yearly...

Autoantibodies are an excellent biomarker for both autoimmune disease and cancer, however, some autoantibodies, called common autoantibodies, have been found to occur frequently in healthy individuals. The presence of these common autoantibodies can impede the search for disease-linked autoantibodies or lead to false positives. The identification of...

Autoantibodies are an excellent biomarker for both autoimmune disease and cancer, however, some autoantibodies, called common autoantibodies, have been found to occur frequently in healthy individuals. The presence of these common autoantibodies can impede the search for disease-linked autoantibodies or lead to false positives. The identification of...

Gastric cancer (GC) is a major public health problem in many countries, with more than 1 million new cases, worldwide, in 2020, contributing to almost 800,000 deaths. And new research suggests that GC may be on the rise in the US, particularly among younger adults. Early detection of GC often allows for greater therapeutic options, however, because...

Type 1 Diabetes (T1D) is one of the most common juvenile autoimmune diseases and is characterized by progressive destruction of pancreatic ß-cells. By the time of T1D diagnosis, around 70-90% of pancreatic ß-cells are already dead. T1D patients face many potential health complications and co-morbidities which lead to both personal and societal...

ErbB4 is a receptor tyrosine kinase member with roles in several key pathways associated with cell proliferation, death and differentiation. ErbB4 overexpression is associated with several types of cancers as well as psychiatric and cardiovascular disorders. Currently there are no drugs available for ErbB4-driven pathologies, or methods of identifying...

In 2021, 134,592 people died from lung cancer, or 22% of all cancer deaths. Lung cancer is the leading cause of cancer death overall and among both men and women. While the increased use of CT screening for lung cancer has resulted in a reduction in lung cancer mortality, it has also resulted in an increased detection of benign pulmonary nodules. Patients...