Autoantibodies are an excellent biomarker for both autoimmune disease and cancer, however, some autoantibodies, called common autoantibodies, have been found to occur frequently in healthy individuals. The presence of these common autoantibodies can impede the search for disease-linked autoantibodies or lead to false positives. The identification of...

ErbB4 is a receptor tyrosine kinase member with roles in several key pathways associated with cell proliferation, death and differentiation. ErbB4 overexpression is associated with several types of cancers as well as psychiatric and cardiovascular disorders. Currently there are no drugs available for ErbB4-driven pathologies, or methods of identifying...

In 2021, 134,592 people died from lung cancer, or 22% of all cancer deaths. Lung cancer is the leading cause of cancer death overall and among both men and women. While the increased use of CT screening for lung cancer has resulted in a reduction in lung cancer mortality, it has also resulted in an increased detection of benign pulmonary nodules. Patients...

Despite recent advances in early detection and treatment, breast cancer remains a common and devastating health problem. Mammography screening detects only 70% of breast cancers and is particularly limited with basal-like subtype cancers (BLBCs). Additionally, BLBCs often present in women younger than 50, and those women are not recommended for routine...

As more and more genomic sequencing data is gathered, further light is being shed on all the somatic mutations in cancer. These mutations include unique combinations of driver and passenger mutations; there could be hundreds of such mutations of which only a small number contribute to cancer progression. Figuring out the relevant combinations of mutations...