­The study of human genetics is a rapidly expanding field, fueled in part by developments in large-scale protein and genomic sequencing technologies. Biopharmaceutical companies and modern healthcare rely heavily on sequencing technologies and the acquired data to develop new drugs and provide effective treatments to patients. However, the results...

In 2021, 134,592 people died from lung cancer, or 22% of all cancer deaths. Lung cancer is the leading cause of cancer death overall and among both men and women. While the increased use of CT screening for lung cancer has resulted in a reduction in lung cancer mortality, it has also resulted in an increased detection of benign pulmonary nodules. Patients...

Ovarian cancer is one of the most common cancers among women, with over 21,000 new cases and over 14,000 deaths per year. If detected early, the 5-year survival rate is over 80%, but that drops to just 11% if detected at stage IV, and over 60% of patients are diagnosed with advanced disease. Early detection is hampered by limitations in current biomarkers,...

Crohn’s disease (CD), is an inflammatory bowel disease that affects about 3 out of 1,000 people in the U.S. It is currently not known what causes CD, but hereditary, environmental factors and a dysregulated immune system are thought to play a role. Diagnosis of CD is difficult and often involves expensive imaging and invasive biopsies. Current...

There are many methods to analyze molecular libraries (e.g. peptide libraries, nucleic acid libraries, libraries of polymeric or multipart structures) in terms of their functional properties. Often, these methods relate the covalent structure of the molecules in libraries to their function based on consensus sequence analysis. However, many biological...

Microarray technology has dramatically advanced the study of protein interactions and validation of new biomarkers and therapeutics. However, current microarray technology suffers from several key limitations that hinder it from gaining broader utility: 1) both the printing and analysis steps consume large sample volumes, which is particularly problematic...