In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...

Passive, wireless stimulators have received significant interest due to their ability to provide therapy and rehabilitation by targeting an organ with monophasic or biphasic stimulation pulses. Wireless stimulators are advantageous because they reduce the risk of infection and inflammation by eliminating wires that protrude through the skin. Extending...

Electrocorticography (ECoG) arrays are clinically useful in monitoring and recording electrical activity from the cerebral cortex either during surgery or prior to surgery for localizing surgical sites, such as epileptic foci. In terms of recording neural activity, ECoG has much greater spatial specificity than other techniques because it eliminates...

External ventricular drainage (EVD) is considered to be the standard of care for CSF diversion and intracranial pressure (ICP) monitoring. However, EVD is an invasive procedure that requires the placement of a catheter into a hole drilled into the cranium. The catheter monitors pressure gradients in many spaces such as intraventricular, intraparenchymal,...