Search Results - neurodegenerative+disease+technologies

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  1. Antibody based reagents that specifically recognize toxic oligomeric forms of beta-amyloid
    Neurodegenerative diseases such as Alzheimer’s are affecting an increasing number, with annual new diagnoses approaching one-half million; and total cost, $150 billion. Early diagnosis and treatment are important for optimal outcomes, yet there is currently no test to detect such diseases in their early, asymptomatic stages. Active immuniza-tion...
    Published: 8/27/2025
    Inventor(s): Michael Sierks, Srinath Kasturirangan
    Keywords(s): Bio-Technology, Therapeutics
    Category(s): Life Science (All LS Techs), Diagnostic Assays/Devices, Neurodegenerative Disease Technologies, Non-Cancer Therapeutics, Proteomic Assays/Reagents/Tools, Medical Diagnostics/Sensors
  2. Compounds to Modulate Retinoid X Receptors
    The human retinoid X receptors (RXRs) function as transcriptional regulators, often in partnership with members of a larger nuclear receptor family of transcription factors. RXR agonists have been shown to modulate RXR transcription and activate or repress various biological pathways and effect therapeutic results for various conditions. There are a...
    Published: 8/27/2025
    Inventor(s): Carl Wagner, Peter Jurutka, Pamela Marshall, Arjan Van Der Vaart
    Keywords(s): Bio-Technology, Drug Screening
    Category(s): Life Science (All LS Techs), Cancer Therapeutics, Pharmaceuticals, Neurodegenerative Disease Technologies, Non-Cancer Therapeutics
  3. Modulating the Production of Neuroactive Molecules by Gut Microbes
    Inhibitory neurotransmitters, such as y-aminobutyric acid (GABA), taurine, taurine analogs and β-alanine, have been associated with neurological disorders such as epilepsy, schizophrenia, dementia, autism, Alzheimer’s disease (AD) and more. Additionally, gut microbiome dysbiosis has also been linked to many neurological disorders, with modulations...
    Published: 8/27/2025
    Inventor(s): Dhara Shah, Pavani Dadi
    Keywords(s):  
    Category(s): Proteomic Assays/Reagents/Tools, Pharmaceuticals, Neurodegenerative Disease Technologies, Non-Cancer Therapeutics, Microbiome, Life Science (All LS Techs)
  4. Targets and Methods of Diagnosing, Monitoring & Treating Frontotemporal Dementia
    Diverse pathologies, especially related to early protein misfolding and aggregation, are observed in different neurodegenerative diseases. Some protein variants result in different proteinopathies that vary from patient to patient, highlighting a need for personalized diagnostic tests to enable accurate diagnoses. Frontotemporal dementia (FTD) refers...
    Published: 8/27/2025
    Inventor(s): Stephanie Williams, Michael Sierks
    Keywords(s):  
    Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Medical Diagnostics/Sensors, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools, Neurodegenerative Disease Technologies
  5. Reagents Targeting Neurodegenerative Diseases and Traumatic Brain Injury
    Misfolding and aggregation of proteins, such as beta-amyloid (Aß), alpha-synuclein (a-syn), tau and TAR DNA-binding protein 43 (TDP-43), have been strongly correlated with early onset of neurodegenerative diseases such as Alzheimer's Disease (AD), Parkinson's Disease (PD), Frontotemporal Dementia (FTD), amyotrophic lateral sclerosis (ALS) and...
    Published: 8/27/2025
    Inventor(s): Michael Sierks, Stephanie Williams
    Keywords(s): Alzheimer's Disease, Bioassay, biomarker, Neurodegenerative Disorders, Neurological Disorders
    Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Neurodegenerative Disease Technologies, Proteomic Assays/Reagents/Tools, Non-Cancer Therapeutics
  6. Reagents Targeting Neurodegenerative Diseases and Traumatic Brain Injury
    Misfolding and aggregation of proteins, such as beta-amyloid (Aß), alpha-synuclein (a-syn), tau and TAR DNA-binding protein 43 (TDP-43), have been strongly correlated with early onset of neurodegenerative diseases such as Alzheimer's Disease (AD), Parkinson's Disease (PD), Frontotemporal Dementia (FTD), amyotrophic lateral sclerosis (ALS) and...
    Published: 8/27/2025
    Inventor(s): Michael Sierks, Lalitha Venkataraman, Wei Xin
    Keywords(s): Alzheimer's Disease, CNS Therapeutics, Dementias, Neurodegenerative Disorders, Neurological Disorders, Phage display
    Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Neurodegenerative Disease Technologies, Non-Cancer Therapeutics, Proteomic Assays/Reagents/Tools
  7. Reagents Targeting Neurodegenerative Diseases and Traumatic Brain Injury
    Misfolding and aggregation of proteins, such as beta-amyloid (Aß), alpha-synuclein (a-syn), tau and TAR DNA-binding protein 43 (TDP-43), have been strongly correlated with early onset of neurodegenerative diseases such as Alzheimer's Disease (AD), Parkinson's Disease (PD), Frontotemporal Dementia (FTD), amyotrophic lateral sclerosis (ALS) and...
    Published: 8/27/2025
    Inventor(s): Michael Sierks, Stephanie Williams, Lalitha Venkataraman
    Keywords(s): AFM, Antibody Therapeutics, Antigen-specific Therapies, Bioassay, Bio-Technology, CNS Therapeutics, Therapeutics
    Category(s): Life Science (All LS Techs), Neurodegenerative Disease Technologies, Non-Cancer Therapeutics, Proteomic Assays/Reagents/Tools, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices
  8. Methods Utilizing Online and Offline Trigeminal Nerve Stimulation to Enhance Visuomotor Learning
    It is widely recognized that neuromodulation can relieve some symptoms of neurological disorders as well as enhance neuroplasticity, learning and recovery of function. While most work has focused on direct neuromodulation to stimulate the cortex and evoke a cortical response, more recent studies have shown that indirect approaches may also enhance neuroplasticity...
    Published: 8/27/2025
    Inventor(s): Christopher Buneo, Diego Arias
    Keywords(s):  
    Category(s): Life Science (All LS Techs), Medical Devices, Neurodegenerative Disease Technologies, Rehabilitation/Physiotherapy
  9. Label-Efficient Learning and Continuous Monitoring of Motor Function Symptoms
    Parkinson’s disease (PD) is a progressive neurodegenerative disorder of the central nervous system affecting both motor and non-motor functions. It is characterized by weakened and damaged neurons and eventually neuronal death. PD significantly impacts quality of life, thus in-home monitoring, particularly of Freezing of Gait (FoG), is paramount...
    Published: 5/28/2025
    Inventor(s): Hassan Zadeh, Shovito Barua Soumma
    Keywords(s):  
    Category(s): Artificial Intelligence/Machine Learning, Computing & Information Technology, Life Science (All LS Techs), Neurodegenerative Disease Technologies, Wearable
  10. Methods for Enhancing Production of Beneficial Short- and Medium- Chain Fatty Acids by the Gut Microbiome
    Short-chain fatty acids (SCFAs) which include acetate (C2), propionate (C3) and butyrate (C4) are important, health-benefiting metabolites, produced when microbes in the human colon ferment polysaccharides and dietary fiber. Medium-chain fatty acids (MCFAs), such as caproate (C6) and caprylate (C8), have also been shown to provide health benefits and...
    Published: 2/13/2025
    Inventor(s): Anca Delgado, Rosa Krajmalnik-Brown, Dorsa Daeizadeh
    Keywords(s):  
    Category(s): Life Science (All LS Techs), Microbiome, Neurodegenerative Disease Technologies, Cancer, Cancer Therapeutics

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