Biological pattern formation requires complex gene regulation networks and accurate cell-cell coordination. The reaction-diffusion (RD) based clock and wavefront model has been proposed as a mechanism involved in biological pattern formation of repeated and segmented structures. While RD driven pattern formation has been demonstrated in many systems,...

Glioblastoma multiforme (GBM) is a highly aggressive malignant brain tumor with a median survival of just over one year. As observed with MRI, it has a heterogeneous morphology, but typically contains an inner, necrotic core with an outer contrast-enhancing rim and often has extensive tumor-associated edema beyond that. Previous analyses have appeared...