The ability to detect small molecules and other chemical analytes is important for many applications from assessing drinking water to monitoring effluents and ensuring food and drinks are safe to consume. While synthetic biology has enabled the development of molecular biosensors, such as transcription factors, to detect small molecules, they rely on...

Compared to nucleic acid tests, current immunoassays suffer from low specificity and poor sensitivity. Attempts have been made to combine protein detection with nucleic acid amplification schemes to increase sensitivity, however, these techniques require multiple processing steps and are limited to fluorescent readout or the use of thermal cycling,...

Accurate detection and diagnosis of infectious diseases is paramount to appropriate treatment and better outcomes. Despite tremendous efforts to advance new diagnostic techniques, there are still critical gaps in the healthcare system in quickly diagnosing and responding to infectious diseases. Current diagnostic technologies identify pathogens by detecting...