T cell receptors (TCRs) play an important role in the adaptive immune system. The ability to accurately predict or characterize binding interactions between TCRs and target antigens, partly because of the vast diversity of TCRs and epitopes, is challenging. While there has been progress in the development of computational models dedicated to this, the...

The ability to determine molecular binding is crucial in drug screening, biomarker detection, and understanding biological processes at the molecular level. Many methods for looking at binding kinetics, such as liquid chromatography, mass spectrometry, western blot, etc., are time consuming, cause protein fragmentation/denaturation and do not allow...

The ability to determine molecular binding is crucial in drug screening, biomarker detection, and understanding biological processes at the molecular level. Many methods for looking at binding kinetics, such as liquid chromatography, mass spectrometry, western blot, etc., are time consuming, cause protein fragmentation/denaturation and do not allow...

Temperature is a critical parameter for cellular activity regulations. Common temperature control techniques for cellular analyses utilize heating sources, which are often nonuniform over the target surface and time consuming. Plasmonic absorption of light, has been shown to be efficient in regulating localized heat rapidly and feasibly. It can be used...

Exosomes play an important role in many cellular processes including communication, immune response, signal transduction, antigen presentation and more. As such, exosome analysis is a promising tool for both biological and clinical research applications. However, exosome detection and biomarker quantification is challenging due to their small size and...

Laparoscopic surgery, also called minimally invasive surgery, has become popular for many reasons. These procedures require smaller incisions, which reduces the patient’s pain, requires less medication, and allows the patient to heal more quickly than procedures using traditional surgery. Hospital stays are shorter, allowing the patient to return...