Single-cell and cell cluster optical tomography, or Cell-CT, has found increasing application in life sciences basic research. Two limitations to its use in this area are that it can image only fixed cells, and the lack of thixotropic gels that can support live cells and also satisfy refractive index constraints. Researchers at the Biodesign Institute...

The accurate measurement of potassium ion levels in biological samples is essential given the impact such ion levels have on many aspects of homeo-stasis. Normal potassium levels are important for the maintenance of heart and nervous system function. Traditionally, potassium ions have been measured in plasma or serum using ion-selective electrodes,...

Determination of consumption/secretion rates of single-cell resolution has great potential for delivering detailed insights into early onset and development of various disease states as well as drug and stimulus response. Due the lack of sensitivity of current technologies, this information is difficult to obtain. Single cell measurements in vivo are...

High-dimensional single cell visualization technologies, such as live-cell computed tomography (CT), are redefining the way we view and understand biological systems, particularly when identifying and analyzing cancer cells. Some cell defects on the surface or in the interior of a cell just can't be properly evaluated in two dimensional microscopy....