In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...

Background Robotic prostheses have the potential to change the lives of millions of lower-limb amputees by providing critical support during legged locomotion. Powered protheses specifically enable complex capabilities including level-ground walking, running, or stair climbing, while also enabling reductions in metabolic cost and improvements in ergonomic...