Invention Description Protein allostery is important in many biological processes and drug development. Understanding the mechanisms involved would be highly beneficial for therapeutic interventions. Existing techniques focus primarily on equilibrium dynamics and network analysis for allosteric interaction mapping. Unfortunately, these are limited...

Invention Description Viral evolution, particularly rapid viral evolution, can lead to the emergence of variants of concern. In order to develop effective antiviral strategies, it is essential to understand the molecular mechanisms driving these adaptations. Some research has focused on identifying adaptive mutations and how they impact protein structure...

Invention Description While recent advances have made RNA therapeutics and vaccines more mainstream, they still suffer from drawbacks including high-dosing requirements and the inability for conditional and targeted expression. Further, they can experience off-target gene expression and related side effects as well as challenges in tissue- or cell-specific...

Mycobacterium tuberculosis (TB) remains a major global health threat, causing nearly 1.5 million deaths annually, making it the 13th leading cause of death. While TB is preventable and treatable, multidrug-resistant TB worsens the global health crisis, making diagnosis and treatment more complex. An even greater challenge is heteroresistance, where...

Glycolysis inhibition in cancer cells has long been recognized as a viable strategy to prevent cancer cell growth. Cancer cells are known to have a high glucose consumption rate as a metabolism adaptation mechanism called the Warburg effect. Activated immune cells also rely on glycolysis for their energy needs. For example, glycolysis is essential for...

M23-139L – Inducing or Rescuing Glycolysis in Cancer Cells. Compositions that selectively block glycolysis in cancer cells while simultaneously enable glycolysis in non-cancer cells, such as macrophages, T cells, NK cells, etc. Vaccine formulations have been developed and tested on mice with positive results. Please see the published PCT (WO2024151709A1)...

Traumatic brain injury (TBI) is a major source of death and long-term physical, cognitive and mental disability worldwide, with roughly 27 million new cases each year. In the U.S. alone, this results in almost 70,000 deaths, annually. Although TBIs can affect people of all ages, the risk of getting a TBI is greatest in adolescents, young adults and...

Black-footed ferrets have become one of the most endangered animals in North America due to the emergence of the sylvatic plague, a flea-borne bacterial disease of wild rodents. To mitigate the loss of this species, a sylvatic plague vaccine (SPV) has been developed in combination with a peanut butter bait for oral administration to wildlife. Current...

Background Melioidosis, also commonly known as Whitmore’s disease, is an infection caused by the bacterium Burkholderia pseudomallei (B. pseudomallei) that currently has an estimated mortality rate of 54%. This bacteria lives in contaminated soil and surface water, and can be transmitted to humans or animals through direct contact. This bacterium...

T cell receptors (TCRs) play an important role in the adaptive immune system. The ability to accurately predict or characterize binding interactions between TCRs and target antigens, partly because of the vast diversity of TCRs and epitopes, is challenging. While there has been progress in the development of computational models dedicated to this, the...