Labware receptacles, such as cell culture flasks or biodomes, are ubiquitous tools in cellular biology research which allow for growing as well as imaging cells. However, many labware receptacles face challenges when trying to image them, such as an inability to lay flat against the stage of a microscope, or to reproducibly place the receptacle in the...

Amyotrophic Lateral Sclerosis (ALS) is a terminal neurodegenerative disease defined by the progressive loss of motor neuron function. Despite intense research efforts, clinical outcomes in ALS patients have remained limited. Because there are no diagnostic or prognostic biomarkers for ALS, patients are classified based on the site of symptom onset,...

Optical characterization of cells and tissues is necessary to understanding physiological mechanisms. However, current optical imaging techniques have limited imaging depth, often because of strong optical scattering. Photoacoustic imaging (PAI) is a powerful technique which combines the high contrast of optical imaging with the high spatial resolution...

Cuvettes, used to measure the absorbance of light in spectroscopy, are designed to hold a small volume of liquid sample and are optically transparent to allow light to pass through the sample. They are highly useful in spectrophotometry, fluorescence spectroscopy, UV spectroscopy and photoacoustic spectroscopy. While the optical characteristics of the...

Micropipettes are a common laboratory instrument utilized in many fields ranging from cell manipulation to conductance microscopy and electrophysiology. Current optical micropipettes, including electrodes, are unable to simultaneously emit and collect light, which is needed in some in vivo procedures, particularly those requiring incremental steps of...

Perfusion is utilized in the field of electrophysiology to maintain a tissue sample during whole cell patching or other electrophysiology experiments, particularly when recording the electrical activity of neurons or other cells. Electrophysiology provides a high-resolution recording of the activity of these cells, often to compare healthy and disease...

-collapse: collapse; } ­Volatile organic compounds (VOC) from different cell sources (cultured, animal or human) provide a wealth of untapped information regarding metabolic processes. They hold great potential for use as biomarkers for early non-invasive monitoring of cancer, infection and organ damage or failure. There are currently no technologies...

Invention Description Photoacoustic microscopy (PAM), the imaging technique that generates acoustic waves caused by thermal expansion due to optical absorption, has been successfully utilized to provide absorption-based contrast at unparalleled depths. Recent advancements in PAM have enabled contrast-free image reconstructions of subcellular components...

The activity of neurons has long been studied to characterize and understand neurological activity. Neurological activity is directly related to changes in membrane potential due to ion flux across the neuronal membrane. Imaging of this ion flux can provide insight into neural activity and enable research into function and disorders. Current approaches...

The activity of neurons has long been studied to characterize and understand neurological activity. Neurological activity is directly related to changes in membrane potential due to ion flux across the neuronal membrane. Imaging of this ion flux can provide insight into neural activity and enable research into function and disorders. Current approaches...