Molecular diagnostics is a rapidly growing area in personalized medicine. The most commonly used immunological technologies can effectively measure proteins at concentrations above 10-12M. Unfortunately, many protein markers are found at concentrations below 10-15M. Signal amplification techniques have been developed to increase sensitivity but they...

Microarray technology has dramatically advanced the study of protein interactions and validation of new biomarkers and therapeutics. However, current microarray technology suffers from several key limitations that hinder it from gaining broader utility: 1) both the printing and analysis steps consume large sample volumes, which is particularly problematic...