Misfolding and aggregation of proteins, such as beta-amyloid (Aß), alpha-synuclein (a-syn), tau and TAR DNA-binding protein 43 (TDP-43), have been strongly correlated with early onset of neurodegenerative diseases such as Alzheimer's Disease (AD), Parkinson's Disease (PD), Frontotemporal Dementia (FTD), amyotrophic lateral sclerosis (ALS) and...

Molecular diagnostics is a rapidly growing area in personalized medicine. The most commonly used immunological technologies can effectively measure proteins at concentrations above 10-12M. Unfortunately, many protein markers are found at concentrations below 10-15M. Signal amplification techniques have been developed to increase sensitivity but they...