Mycobacterium tuberculosis (TB) remains a major global health threat, causing nearly 1.5 million deaths annually, making it the 13th leading cause of death. While TB is preventable and treatable, multidrug-resistant TB worsens the global health crisis, making diagnosis and treatment more complex. An even greater challenge is heteroresistance, where...

Glycolysis inhibition in cancer cells has long been recognized as a viable strategy to prevent cancer cell growth. Cancer cells are known to have a high glucose consumption rate as a metabolism adaptation mechanism called the Warburg effect. Activated immune cells also rely on glycolysis for their energy needs. For example, glycolysis is essential for...

M23-139L – Inducing or Rescuing Glycolysis in Cancer Cells. Compositions that selectively block glycolysis in cancer cells while simultaneously enable glycolysis in non-cancer cells, such as macrophages, T cells, NK cells, etc. Vaccine formulations have been developed and tested on mice with positive results. Please see the published PCT (WO2024151709A1)...

Traumatic brain injury (TBI) is a major source of death and long-term physical, cognitive and mental disability worldwide, with roughly 27 million new cases each year. In the U.S. alone, this results in almost 70,000 deaths, annually. Although TBIs can affect people of all ages, the risk of getting a TBI is greatest in adolescents, young adults and...

Black-footed ferrets have become one of the most endangered animals in North America due to the emergence of the sylvatic plague, a flea-borne bacterial disease of wild rodents. To mitigate the loss of this species, a sylvatic plague vaccine (SPV) has been developed in combination with a peanut butter bait for oral administration to wildlife. Current...

Background Melioidosis, also commonly known as Whitmore’s disease, is an infection caused by the bacterium Burkholderia pseudomallei (B. pseudomallei) that currently has an estimated mortality rate of 54%. This bacteria lives in contaminated soil and surface water, and can be transmitted to humans or animals through direct contact. This bacterium...

T cell receptors (TCRs) play an important role in the adaptive immune system. The ability to accurately predict or characterize binding interactions between TCRs and target antigens, partly because of the vast diversity of TCRs and epitopes, is challenging. While there has been progress in the development of computational models dedicated to this, the...

Recombinant protein subunit vaccines offer an improved safety profile compared to live attenuated or inactivated vaccines, making them a promising vaccine strategy. These vaccines can further enhance immunogenicity through fusion with IgG-based protein scaffolds, such as immune complex (RIC) platforms. RIC consists of an antibody and antigen complex...

Vaccines are an essential tool in preventing and controlling many diseases. Most approved vaccines are inactivated or live attenuated type, however, alternative platforms like mRNA and virus-like particles (VLPs) are being increasingly explored and approved because they generate potent immune responses with great safety profiles. VLPs are particularly...

T cell immunity is a fundamental component of the immune response to infections, cancer, and autoimmunity and is strongly impacted by polymorphisms in major histocompatibility complex (MHC) protein sequences. In particular, allelic MHC-I protein variants have been shown to influence patient outcomes to various viral infections, including SARS-CoV. While...