Invention Description Accurately identifying and sequencing rare genotypes within complex cell populations remains a major challenge across biological research. Conventional sequencing approaches often require large amounts of high-quality DNA, struggle with heterogeneous or degraded samples, and fail to retain the spatial or cellular context necessary...

Invention Description Pediatric Inflammatory Bowel Disease (IBD), encompassing Crohn’s Disease and Ulcerative Colitis, presents significant clinical challenges due to its complex and heterogeneous nature, often leading to lifelong health complications. Current diagnostic and therapeutic strategies are limited by an incomplete understanding of...

Invention Description Understanding of the pathobiology of Alzheimer’s disease (AD) has long been fragmented, with much research centered around biological mechanisms including amyloid β or tau proteins, inflammation, cell death pathways, glia, mitochondria and more. While these all deal with real facets in the biology of AD, they are limited...

Implementing liquid-based assays, such as PCR and LAMP, is difficult in POC microfluidic devices, due to bubble formation. To mitigate this, auxiliary metering systems or actuators are required to regulate consistent flow rates. This can make the microfluidic device more complicated to operate, increases cost, and limits rapid prototyping, ultimately...

Point-of-care (POC) testing techniques are essential in molecular diagnostics, particularly in resource-limited settings. The first step in molecular diagnostics is sample preparation which may include extraction of nucleic acids (NAs). Simple and efficient NA extraction is crucial for downstream applications such as pathogen detection, genetic analysis,...

The blood brain barrier (BBB) is a highly selective semipermeable complex, and only about 2% of small molecules in the blood can penetrate it. Because of this, drug delivery to the brain is fairly ineffective. Research into receptors expressed on the BBB is promising, however, many receptors (glucose transporter 1, transferrin receptor, LDL-receptor...

The incidence of inflammatory bowel disease (IBD), which includes Chron’s disease (CD) and ulcerative colitis (UC), is increasing globally, as is the healthcare burden, with studies showing it as one of the top 5 most expensive GI conditions. Early and accurate diagnosis is strongly associated with better patient outcomes. However, the common...

Neurodegenerative diseases such as Alzheimer’s are affecting an increasing number, with annual new diagnoses approaching one-half million; and total cost, $150 billion. Early diagnosis and treatment are important for optimal outcomes, yet there is currently no test to detect such diseases in their early, asymptomatic stages. Active immuniza-tion...

Diverse pathologies, especially related to early protein misfolding and aggregation, are observed in different neurodegenerative diseases. Some protein variants result in different proteinopathies that vary from patient to patient, highlighting a need for personalized diagnostic tests to enable accurate diagnoses. Frontotemporal dementia (FTD) refers...

Misfolding and aggregation of proteins, such as beta-amyloid (Aß), alpha-synuclein (a-syn), tau and TAR DNA-binding protein 43 (TDP-43), have been strongly correlated with early onset of neurodegenerative diseases such as Alzheimer's Disease (AD), Parkinson's Disease (PD), Frontotemporal Dementia (FTD), amyotrophic lateral sclerosis (ALS) and...