In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...

Background Current spatial audio techniques for speaker systems are challenged by high cost, high computational intensity, and user mobility. In particular, crosstalk—when sound from a speaker unintentionally reaches an opposite ear—is a major performance-degrading factor. Some spatial audio speaker systems utilize beam-forming techniques...

Background By integrating visual stimuli with perceived tactile sensation, mixed-reality haptic devices provide a critical dimension to otherwise intangible virtual content. Much of the commercial and academic efforts in this domain have focused on delivering simulated interactions with rigid objects, often through the use of vibrotactile gloves, robotic...