It is estimated that more than 6 million Americans may have dementia caused by Alzheimer’s disease (AD). Currently, AD is ranked as the seventh leading cause of death in the US. While several proteins have been implicated in AD, two, beta-amyloid and tau, are considered the defining pathologies of AD. Amyloid and tau imaging has subsequently become...

­Advances in medical imaging, particularly image processing tools, have become invaluable in medical practices. Imaging tools have been developed to map and measure individual glomeruli in the kidney using contrast agents and gradient-echo MR images (CFE-MRI). CFE-MRI provides comprehensive, 3D measurements of histologic features of the kidney to...

Recent studies conclude that a strong correlation exists between the numbers of glomerular in the kidney and renal diseases. These findings generate great interest in accurately counting glomeruli. Traditionally, the glomerulus is counted using histological sections, which have several limitations. First, histology based counting relies on techniques...