Cardiovascular disease is responsible for an estimated 17.9 million deaths each year, making it the leading cause of death worldwide. Continuous heart health monitoring way is the best preventative for heart failure. However, standard monitoring devices, including ECG and PPG, require direct physical contact, which can be difficult for certain patient...

Heart failure is a serious global burden affecting more than 64 million people worldwide. It has high morbidity and mortality and poor quality of life, making it a major public health priority. N-terminal proBNP (NT-pro-BNP) is a well-established clinical biomarker for monitoring and managing heart failure. Regular and frequent monitoring of patients...

Detection and quantification of low-abundance biomarkers is essential to early disease detection, monitoring and treatment. While many techniques, have been developed for measuring single molecules, all require signal amplification, via enzyme amplification, or fluorescence or gold nanoparticle probes, which come with their own unique drawbacks, including...

Acute pulmonary infections, or pneumonia, are a leading cause of infectious death worldwide with more than 2.3 million deaths each year. Existing strategies for diagnosing pneumonia are based on clinical, radiological and microbial criteria, which is time-consuming, low accuracy, and subject to interobserver variability. Furthermore, obtaining a lower...

Detection, identification and quantification of molecular biomarkers, such as proteins, peptides, exosomes, hormones, neurotransmitters, metabolites and nucleic acids, are critical to disease diagnosis, progression monitoring, and management. While there are numerous approaches for analyzing biomarkers, the most validated and well-established is ELISA....

Galectin-1 (Gal-1) is a ubiquitously expressed galactoside-binding 14-kDa lectin that is differentially expressed by a variety of pathological as well as normal cell types. Extracellular Gal-1 has been shown to exert strong Immunomodulatory activity and has been implicated in numerous cancer and autoimmune diseases. Further, recent research has shown...

Quiescin sulfhydryl oxidase1 (QSOX1) is a sulfhydryl oxidase that is overexpressed in several malignancies and as such is a potential biomarker for multiple cancer types as well as acute decompensated heart failure (ADHF). Since its discovery, QSOX1 has been identified as a key player in the facilitation of tumor cell migration, creating a significant...

Chimeric antigen receptor (CAR) T-cell therapy is a type of immunotherapy which uses altered T-cells to target cancer cells more effectively. As such, it has dramatically changed the treatment landscape for cancer patients. However, it has limitations including cytokine release syndrome (CRS), neurological events (NE), lack of response (which occurs...

Amyotrophic Lateral Sclerosis (ALS) is a terminal neurodegenerative disease defined by the progressive loss of motor neuron function. Despite intense research efforts, clinical outcomes in ALS patients have remained limited. Because there are no diagnostic or prognostic biomarkers for ALS, patients are classified based on the site of symptom onset,...

Glucose control is an integral component in both preventing and managing diabetes. Without proper control, hyperglycemic and hypoglycemic events can occur, which increase the risks for cardiovascular disease, eye issues, cancer, seizures and more. While continuous glucose monitors are widespread, their lack of computational abilities hinders their utility...