Invention Description Accurately identifying and sequencing rare genotypes within complex cell populations remains a major challenge across biological research. Conventional sequencing approaches often require large amounts of high-quality DNA, struggle with heterogeneous or degraded samples, and fail to retain the spatial or cellular context necessary...

Invention Description In modern airtight vehicles, the concentration of air pollutants, including CO2, can build up quickly, with some studies showing a rise above 2500 ppmv of CO2 in mere minutes in occupied vehicles. This is particularly noticeable during recirculated air operation and in urban or hot climates where cabin air is recirculated to enhance...

Invention Description Polyaniline (PANI) is a conductive polymer with excellent electrical conductivity lending it great utility in numerous electronics applications including electronic devices, sensors, batteries and more. While PANI can be easily deposited on many surfaces, it has difficulty with producing a dense coating on insulating substrates,...

Point-of-care (POC) testing techniques are essential in molecular diagnostics, particularly in resource-limited settings. The first step in molecular diagnostics is sample preparation which may include extraction of nucleic acids (NAs). Simple and efficient NA extraction is crucial for downstream applications such as pathogen detection, genetic analysis,...

Fluorescence based point-of-care molecular diagnostic systems are ubiquitous in healthcare. However, many tests require that the sample be sent to a reference laboratory and read by trained medical staff which can be expensive and result in delayed analysis. Portable systems have been developed, however, detecting multiple biomarkers requires a different...

Nitric species such as nitric oxides are important environmental pollutants as well as key breath biomarkers of respiratory diseases. A chemical sensor that can quickly, selectively and sensitively detect these analytes will find applications not only in environmental monitoring, but also as a non-invasive medical diagnosis and management device. Current...

Studying single cells is difficult due to the laborious and costly cell isolation procedures which restrict throughput and impede the analysis of large numbers of cells or multiple samples in a single experiment. ASU researchers previously developed a method which used the cell’s membrane as a container for different reactions. One such reaction...

Molecular interactions are integral to virtually all biological processes including cell signaling, enzyme activity, protein functionality, and disease development. Understanding the kinetics of these interactions is crucial for providing detailed quantitative and mechanistic insights, at the molecular level, which are essential for advancements in...

Background The chemical composition of aerosol particles provides key insights into the study of the behavior of planetary atmospheres. Measuring aerosol composition typically involves separating the aerosols from the carrier atmospheric gases, which can be challenging. Current methods for aerosol mass spectrometry (AMS) are well-established in the...

Nanoarray-based assays offer advantages over standard microarray assays such as minimal sample consumption, high efficiency, and enhanced multiplexing capacity. However, despite their potential, they face challenges such as the complexity and high cost of spotting and fabrication, as well as a lack of effective detection schemes. This impedes many practical...