Search Results - michael+sierks

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  1. Reagents Targeting Neurodegenerative Diseases and Traumatic Brain Injury
    Misfolding and aggregation of proteins, such as beta-amyloid (Aß), alpha-synuclein (a-syn), tau and TAR DNA-binding protein 43 (TDP-43), have been strongly correlated with early onset of neurodegenerative diseases such as Alzheimer's Disease (AD), Parkinson's Disease (PD), Frontotemporal Dementia (FTD), amyotrophic lateral sclerosis (ALS) and...
    Published: 2/13/2025
    Inventor(s): Michael Sierks, Stephanie Williams
    Keywords(s): Antibodies, Antigen-specific Therapies, Bioassay, biomarker, ELISA, Mental Disorders, Traumatic Brain Injury
    Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Neurodegenerative Disease Technologies, Non-Cancer Therapeutics, Proteomic Assays/Reagents/Tools
  2. Recombinant Antibody Fragments that Selectively Target Oligomeric Tau Aggregates
    Alzheimer's disease (AD) is one of the most prevalent and feared neurodegenerative diseases associated with aging, characterized by progressive neuronal loss and cognitive dysfunction. AD affects nearly 5 million Americans, and unfortunately, there is no cure as of yet. Numerous studies have implicated oligomeric amyloid beta (Aß) aggregates as...
    Published: 2/13/2025
    Inventor(s): Michael Sierks, Huilai Tian, James Moe, Eliot Davidowitz
    Keywords(s): Antibodies, Antibody Therapeutics, Antigen-specific Therapies, Bioassay, Dementias, Diagnostics, Human aging, Protein, Therapeutics
    Category(s): Life Science (All LS Techs), Neurodegenerative Disease Technologies, Non-Cancer Therapeutics, Diagnostic Assays/Devices, Medical Diagnostics/Sensors, Proteomic Assays/Reagents/Tools
  3. Nanoscale Process to Generate Reagents Selective for Individual Protein Variants
    Protein variants have been associated with many different and devastating human diseases including Alzheimer’s and Parkinson’s diseases, diabetes and cancer. Unfortunately, assessment of these protein variants is technologically difficult, primarily owing to two factors: a lack of binding partners that can distinguish between protein isoforms...
    Published: 2/13/2025
    Inventor(s): Michael Sierks, Mark Hayes
    Keywords(s):  
    Category(s): Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools
  4. Selective Clearance of Beta-Amyloid Using Bispecific Recombinant Antibody fragments
    Alzheimer’s disease (AD) is one of the most prominent and feared neurodegenerative diseases associated with aging. A hallmark of this disease is the formation of extra-cellular amyloid plaques in the brain. The principle component of these extracellular plaques is amyloid-ß protein (Aß). Though the mechanisms underlying Alzheimer’s...
    Published: 2/13/2025
    Inventor(s): Michael Sierks, Yong Shen
    Keywords(s):  
    Category(s): Pharmaceuticals, Life Science (All LS Techs), Neurodegenerative Disease Technologies, Non-Cancer Therapeutics
  5. Bi-specific Antibodies as a Therapeutic for Alzheimer’s Disease
    Alzheimer’s disease (AD) is one of the most prominent and feared neurodegenerative diseases associated with aging. A hallmark of this disease is the formation of extra-cellular amyloid plaques in the brain. The principle component of these extracellular plaques is amyloid-ß protein (Aß). Though the mechanisms underlying Alzheimer’s...
    Published: 2/13/2025
    Inventor(s): Michael Sierks, Shanta Boddapati, Srinath Kasturirangan
    Keywords(s): Bio-Technology, Therapeutics
    Category(s): Life Science (All LS Techs), Neurodegenerative Disease Technologies, Non-Cancer Therapeutics, Pharmaceuticals
  6. Reagents that Distinguish AD and PD Samples
    er-collapse: collapse; } Diverse pathologies, especially related to early protein misfolding and aggregation, are observed in different neurodegenerative diseases. Some protein variants result in different proteinopathies that vary from patient to patient, highlighting a need for personalized diagnostic tests to enable accurate diagnoses. Reagents...
    Published: 2/13/2025
    Inventor(s): Stephanie Williams, Michael Sierks
    Keywords(s):  
    Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors, Neurodegenerative Disease Technologies

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