Invention Description Conducting learning-based models on large-scale unstructured geometric data, particularly volumetric 3D meshes, remains a significant challenge. While previous methods have employed graph convolutional approaches, they suffer from high space complexity, limiting efficient mini-batch training, as well as fixed short-range feature...

Invention Description Chronic and slow-healing wounds, particularly in diabetic and obese patients, pose a significant global, medical, and economic burden due to poor healing outcomes and limited effective treatments. Post-operative complications such as intestinal adhesions further complicate recovery and emphasize the need for targeted wound therapies. ...

Invention Description Lyophilization is a critical process for stabilizing reagents in point-of-care (POC) diagnostics, effectively eliminating the need for cold chain storage and preventing liquid evaporation. While this technology is essential for developing robust field-deployable devices, current industry standards are limited to producing reagents...

Invention Description Protein allostery is important in many biological processes and drug development. Understanding the mechanisms involved would be highly beneficial for therapeutic interventions. Existing techniques focus primarily on equilibrium dynamics and network analysis for allosteric interaction mapping. Unfortunately, these are limited...

Invention Description Viral evolution, particularly rapid viral evolution, can lead to the emergence of variants of concern. In order to develop effective antiviral strategies, it is essential to understand the molecular mechanisms driving these adaptations. Some research has focused on identifying adaptive mutations and how they impact protein structure...

Invention Description Lab-on-a-chip technology and microfluidic diagnostic devices often rely on complex mechanical or electrical systems to manipulate fluid, making them costly and bulky. These components may limit portability, decrease operational lifetime, and prevent widespread use by untrained personnel or patients at the point of care or at home....

Invention Description Rapid and reliable nucleic acid assays are critical for diagnosing infectious diseases at the point of need, yet most systems rely on complex, expensive instrumentation and trained personnel. These requirements limit access to timely diagnostics in low-resource, remote, or decentralized settings. Many platforms typically require...

Invention Description One of the main challenges in nanoscale manufacturing is achieving precise three-dimensional (3D) positioning and organization of materials. DNA nanotechnology, such as DNA origami, offers a solution to this problem by leveraging the predictable base-pairing properties of DNA to design and construct nanoscale structures with molecular...

Invention Description Accurately identifying and sequencing rare genotypes within complex cell populations remains a major challenge across biological research. Conventional sequencing approaches often require large amounts of high-quality DNA, struggle with heterogeneous or degraded samples, and fail to retain the spatial or cellular context necessary...

Invention Description Type 1 diabetes (T1D) is an autoimmune disease where the body attacks and destroys insulin-producing beta cells in the pancreas and affects nearly 10 million people globally. Because glucose needs to be continuously monitored for precise insulin dosing, managing T1D is challenging. While automated insulin delivery (AID) systems...