Understanding the relationship between protein sequence-structure and binding dynamics is not well understood. Of particular interest is the ability to relate foldability and function of a protein and the ability to characterize how foldability and binding change based on mutations in the protein sequence. WW domains are one of the most abundant independently...

Histological whole slide image (WSI) processing techniques are critical for identifying and classifying tissues, particularly cancerous tissues. AI-aided methods for analyzing these WSIs have become increasingly important to enhance diagnostic precision and high throughput processing. However, WSIs have gigapixel resolution, leading to computational...

Air quality monitoring is critical for environmental health and public safety. Traditional monitoring methods rely on passive and active air sampling techniques, which, while effective, are cumbersome, expensive and limited with respect to real-time data and comprehensive analyses. In high-risk environments, such as hospital or care settings, and food...

Parkinson’s disease (PD) is a progressive neurodegenerative disorder of the central nervous system affecting both motor and non-motor functions. It is characterized by weakened and damaged neurons and eventually neuronal death. PD significantly impacts quality of life, thus in-home monitoring, particularly of Freezing of Gait (FoG), is paramount...

Retinal color fundus photography (CFP) is an imaging technique for capturing detailed images of the back of the eye, including the retina, optic nerve and blood vessels. CFP is non-invasive and offers a safe and painless means to diagnose and monitor a variety of eye conditions such as retinopathy, glaucoma and macular degeneration. High quality retinal...

Next-generation sequencing (NGS) technologies have revolutionized genomics research because they enable faster, cheaper and accurate decoding of nucleotide sequences. This has resulted in breakthroughs in diagnostics, disease risk assessment, personalized medicines, screening and more. However, despite all the NGS-related advancements that have been...

Antimicrobial resistance is one of the biggest global health crises we are currently facing, and it is being accelerated by the overuse and misuse of antibiotics. There is a tendency, especially in pediatrics, to prescribe antibiotics for viral infections, or to withhold an antibiotic out of an abundance of caution. A contributing factor in antibiotic...

Mycobacterium tuberculosis (TB) remains a major global health threat, causing nearly 1.5 million deaths annually, making it the 13th leading cause of death. While TB is preventable and treatable, multidrug-resistant TB worsens the global health crisis, making diagnosis and treatment more complex. An even greater challenge is heteroresistance, where...

The Caribbean region is considered a coral disease hotspot, with over 20 documented diseases and syndromes affecting over 20 species of corals. One motile marine pathogen family, Vibrionaceae, which is responsible for 50% of coral diseases, is strongly thermodependent, thus warming sea-surface temperatures, driven by pollution and global climate change,...

DNA and RNA nanostructures, e.g., DNA Origami, have great potential in biological applications, including extracellular matrix scaffolds and delivery vehicles for drugs and gene therapies. While folding DNA origami under physiological conditions is plausible, significant challenges and limitations remain. For example, isothermal annealing of DNA origami...