Pain is estimated to affect about 30% of the world’s population and treatment is challenging because of issues with addiction and withdrawal which accompany many current analgesics. Human TRPV1 is a widely expressed nociceptor and is a desirable target to modulate diverse human pathophysiologies, including pain, obesity, and diabetes, among others....

Antigen-specific immune suppression or tolerance is a highly attractive strategy to prevent inflammation-induced tissue damage in rheumatoid arthritis (RA). Although there is insufficient knowledge about autoantigens in human RA, generating and expanding synovium-specific regulatory T cells, and suppressing synovium-specific follicular T-helper cells,...

There is a rich history of successful drug delivery carriers made of biodegradable biomaterials. Biomaterials may degrade into metabolic by-products, which are capable of modulating the function of immune cells, including alpha-ketoglutarate (aKG), which induces alternative activation (immunosuppressive phenotype) in macrophages through metabolic reprogramming....

M23-139L – Inducing or Rescuing Glycolysis in Cancer Cells. Compositions that selectively block glycolysis in cancer cells while simultaneously enable glycolysis in non-cancer cells, such as macrophages, T cells, NK cells, etc. Vaccine formulations have been developed and tested on mice with positive results. Please see the published PCT (WO2024151709A1)...

Stress related psychiatric disorders (SRPDs) such as post-traumatic stress disorder (PTSD), major depressive disorder (MDD), mood disorders, psychotic disorders, anxiety disorders, substance use disorders (SUDs) and more, are a leading disease burden worldwide with increasing diagnoses among adolescents as well as adults. They are influenced by both...

The complement system is part of the immune system and is important in both innate and adaptive immunity. However, the complement system can also be a pathogenetic factor in many diseases including, rheumatoid arthritis, reperfusion injury, myasthenia gravis, and more. Complement has also been shown to be important for the development of antibodies...

Traumatic brain injury (TBI) is a major source of death and long-term physical, cognitive and mental disability worldwide, with roughly 27 million new cases each year. In the U.S. alone, this results in almost 70,000 deaths, annually. Although TBIs can affect people of all ages, the risk of getting a TBI is greatest in adolescents, young adults and...

Atherosclerosis is characterized by the formation of fatty plaque deposits within the vasculature. With increasing plaque buildup, the affected arteries may harden and narrow leading to complications such as heart attack, stroke, aneurysm and other cardiovascular events. The complex nature of plaque makes lesion-targeting imaging, and subsequently early...

Background Melioidosis, also commonly known as Whitmore’s disease, is an infection caused by the bacterium Burkholderia pseudomallei (B. pseudomallei) that currently has an estimated mortality rate of 54%. This bacteria lives in contaminated soil and surface water, and can be transmitted to humans or animals through direct contact. This bacterium...

Obesity and related metabolic diseases are a significant public health issue in the US and worldwide. Studies have shown that pathologically expanded white adipose tissue is associated with multiple obesity-related comorbidities including diabetes, cardiovascular disease as well as certain types of cancer. Current strategies to combat obesity and metabolic...