Traditional bulk diagnostic assays suffer from signal dilution and averaging, making it difficult to detect rare biomarkers and subtle molecular variations critical for early disease diagnosis. Microarrays address this limitation by enabling high-throughput, multiplexed analysis with improved specificity and sensitivity. Their structured array format...

High throughput parallel assays are needed to effectively identify and study biomolecules and their activity. Typically it takes a large number of repeated assays to get statistically significant data for studying biomolecules. However, fewer assays would be needed to get statistically meaningful results if the data were of higher quality. Because of...

Array technologies allow scientists to perform large-scale, quantitative, biological analyses such as biomarker discovery, immunomonitoring, epitope mapping and so on. In situ synthesized arrays have advantages in feature density, and sensitivity, however, quality and reliability rely on the quality and consistency of the synthesized molecules. A critical...

There are many methods to analyze molecular libraries (e.g. peptide libraries, nucleic acid libraries, libraries of polymeric or multipart structures) in terms of their functional properties. Often, these methods relate the covalent structure of the molecules in libraries to their function based on consensus sequence analysis. However, many biological...

Approximately 9% of the general population will report the onset of Irritable Bowel Syndrome (IBS) over a one year period. Unfortunately, at present, there is no standard and reliable diagnostic test for IBS. IBS is currently diagnosed using symptomatic criteria, but because symptoms of IBS can overlap with other GI diseases, there is considerable uncertainty...