­Owing to an increasing number of drug resistant bacteria, as well as similarity in the activity spectrum of current antibiotics, there is high demand for developing effective and specific antimicrobial therapies. Nontuberculous mycobacteria, specifically Mycobacterium abscessus (M. abscessus), have become an increasing public health concern in...

The development of new drugs and diagnostic assays requires the ability to identify and prepare high-affinity, high-specificity ligands. Monoclonal antibodies are useful reagents in this regard, but are difficult to humanize and express in large amounts. Monoclonal antibodies are also intrinsically limited by the immunological repertoire of the immunized...

Antimicrobial resistance is one of the biggest healthcare challenges. Overuse and misuse of conventional antibiotics along with their broad spectra have triggered development of multi-drug resistant superbugs. Researchers at Arizona State University have developed a novel process for producing alternative antimicrobial agents specific for any particular...

Noroviruses are hardy, highly contagious viruses that are the most common cause of acute gastroenteritis in humans. The CDC estimates that there are about 21 million illnesses caused by Noroviruses each year and about 800 of those result in death. There is no available vaccine for Norovirus infection and vaccine progress is hampered by the absence of...

Highly virulent strains of influenza virus are a critical public health concern with 3,000-5,000 people dying each year from influenza infection in the United States alone. Influenza is a continually evolving pathogen that develops resistance easily, including to recently approved antivirals. Rapidly diagnosing and typing influenza is essential in surveillance...

Antibiotic resistance is a worldwide clinical and public health problem, primarily stemming from the overuse of antibiotics. One of the most critical resistant pathogens is Methicillin-resistant Staphylococcus aureus (MRSA), which accounts for over 2,000,000 illnesses and 11,000 deaths each year. MRSA has developed resistance to all beta-lactam antibiotics....

Antibiotic resistance is a worldwide clinical and public health problem, primarily stemming from the overuse of antibiotics. One of the most critical resistant pathogens is Methicillin-resistant Staphylococcus aureus (MRSA), which accounts for over 2,000,000 illnesses and 11,000 deaths each year. MRSA has developed resistance to all beta-lactam antibiotics....

Noroviruses are the leading cause of gastroenteritis and foodborne illness, affecting millions and causing nearly $60 billion in societal costs each year. They are highly contagious and persist in the environment, resulting in frequent outbreaks in healthcare facilities, hospitals, schools and cruise ships. Further, these viruses can lead to severe...

Two-dimensional microarrays have proven useful for a wide range of applications, from ELISA microarrays to basic protein research. However, attaching an antibody, enzyme, or other protein to a functionalized surface is not without its problems. Antibodies are costly and time-consuming to produce and screen, and the process of attaching a protein often...